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Protein Kinases

Protein Kinases

Protein kinases are enzymes that transfer phosphate groups from donor molecules to specific proteins by a process referred as phosphorylation. Protein kinases are key regulators of cell functions modulating activity, cellular localization and overall functions of about 30% of human proteins. Representing about 2% of all human genes, more than 500 human protein kinase s can be classified in seven majors groups:

  • AGC kinases containing PKA, PKC and PKG.
  • CaM kinases- containing the calcium/calmodulin-dependent protein kinases
  • CK1- containing the casein kinase 1 group
  • CMGC containing CDK, MAPK, GSK3 and CLK kinases
  • STE - containing the homologs of yeast Sterile 7, Sterile 11, and Sterile 20 kinases
  • TK- containing the tyrosine kinases
  • TKL - containing the tyrosine-kinase like group of kinases


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