• High siRNA transfection efficiency
• Functional gene silencing post siRNA delivery
• Compatibility with diverse growth conditions (with and without serum)
• Low cytotoxicity
• Easy-to-use protocols for both adherent and suspension cells

GeneSilencer^® siRNA Transfection Reagent is a novel cationic lipid formulation specifically designed for efficient delivery of siRNAs (small interfering RNAs) into a wide variety of cell types.

"In contrast [to the Mouse Nucleofector kit from Amaxa Biosystems and transfection reagents from Santa Cruz Biotechnology], the most effective method was the lipid-based method using the siRNA transfection reagent GeneSilencer from Genlantis. This protocol resulted in up to 92% FITC-siRNA positive cells after 4 h which declined to 62% and 59% 24 and 48 h post-transfection, respectively. The transfected BM-DC remained CD11c positive, expressed high MHC class II and intermediate CD40 and were functional as APC.."

GeneSilencer Primary Cell Citations

Aortic Muscle Cells	Cerebellar Neurons	Hippocampal Neurons	Osteoblast
Aveolar Type II Cells	Coronary Artery Endothelial	HMVEC	Pulmonary Artery Endothelium
Bone Marrow	Cortical Neurons	Lacrimal Gland Acinar Cells	Retinal Ganglion
Cardiac Fibroblast	Dendritic Cells	Lung Microvascular Endothelial Cells	Schwann Cells
Cardiac Myocytes	Dorsal Root Ganglion Neurons	Macrophage	T-Cells (CD3+)